Myer will return to the Virgin Australia Melbourne Fashion Festival this year.
For the first time in five years, the department store will showcase its autumn collections as part of the program.
Myer will host two fashion runway shows in its flagship store on March 11 at 5:30pm and 7pm.
Myer ambassadors Jennifer Hawkins and Kris Smith will grace the runway in front of 1000 Myer customers and media.
Myer chief merchandise and marketing officer Daniel Bracken said the partnership is a perfect fit.
"Myer is excited to be returning as an official sponsor of Virgin Australia Melbourne Fashion Festival for 2016.
"As Australia's largest department store group, we are thrilled to once again align our brand with Australia's premier fashion and retail event.
"Our focus is on delivering wonderful experiences that combine wanted brands with the theatre of shopping that we know customers love."
The Festival will feature a public program of over 140 events from March 7 to 13 at its new home, Melbourne Museum Precinct, and venues throughout Victoria.